Stuart Firth‐Clark
Domainex (United Kingdom)(GB)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Click Chemistry and Applications, Protein Structure and Dynamics, Estrogen and related hormone effects, Cancer therapeutics and mechanisms
Most-Cited Works
- → Assessment of Binding Affinity via Alchemical Free-Energy Calculations(2020)220 cited
- → New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival(2017)70 cited
- → Including Tightly-Bound Water Molecules in de Novo Drug Design. Exemplification through the in Silico Generation of Poly(ADP-ribose)polymerase Ligands(2005)44 cited
- → Generation and Selection of Novel Estrogen Receptor Ligands Using the De Novo Structure-Based Design Tool, SkelGen(2005)31 cited
- → Clostridium difficilehas a single sortase, SrtB, that can be inhibited by small-molecule inhibitors(2014)30 cited
- → The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma(2014)28 cited
- → SkelGen: a general tool for structure-basedde novoligand design(2006)22 cited
- → De Novo Ligand Design to Partially Flexible Active Sites: Application of the ReFlex Algorithm to Carboxypeptidase A, Acetylcholinesterase, and the Estrogen Receptor(2008)17 cited
- → Exhaustive de novo Design of Low-Molecular-Weight Fragments Against the ATP-Binding Site of DNA-Gyrase(2006)16 cited
- → Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors(2015)11 cited