Mei-Chu Lo
Amgen (United States)(US)
Publications by Year
Research Areas
Cancer-related Molecular Pathways, Microtubule and mitosis dynamics, Ubiquitin and proteasome pathways, Click Chemistry and Applications, Computational Drug Discovery Methods
Most-Cited Works
- → Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery(2004)678 cited
- → Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development(2014)291 cited
- → A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation(2017)199 cited
- → Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction(2012)167 cited
- → Better Substrates for Bacterial Transglycosylases(2001)157 cited
- → Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors(2013)84 cited
- → Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction(2014)83 cited
- → The Kinetic Characterization of Escherichia coli MurG Using Synthetic Substrate Analogues(1999)77 cited
- → Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3(2014)70 cited
- → Identification, Characterization, and Crystal Structure ofBacillus subtilis Nicotinic Acid Mononucleotide Adenylyltransferase(2002)56 cited