Johan W. Smit
BH Consulting (Ireland)(IE)UCB Pharma (Belgium)(BE)
Publications by Year
Research Areas
Drug Transport and Resistance Mechanisms, Pharmacological Effects and Toxicity Studies, Histone Deacetylase Inhibitors Research, Epigenetics and DNA Methylation, Protein Degradation and Inhibitors
Most-Cited Works
- → Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine(1997)878 cited
- → Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan–Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors(2015)380 cited
- → Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure(1999)355 cited
- → Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein(1996)279 cited
- → Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study(2014)251 cited
- → Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism(2007)234 cited