Stephen D. Roughley
Granta Design (United Kingdom)(GB)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Chemical Synthesis and Analysis, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Protein Structure and Dynamics
Most-Cited Works
- → The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates(2011)2,642 cited
- → 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer(2007)442 cited
- → Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design(2005)231 cited
- → Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone(2009)173 cited
- → Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds(2004)114 cited
- → Dynamic undocking and the quasi-bound state as tools for drug discovery(2016)92 cited
- → Synthesis of (−)-Histrionicotoxin by a Tandem Process(1999)86 cited
- → Off-Rate Screening (ORS) By Surface Plasmon Resonance. An Efficient Method to Kinetically Sample Hit to Lead Chemical Space from Unpurified Reaction Products(2014)75 cited
- → How Well Can Fragments Explore Accessed Chemical Space? A Case Study from Heat Shock Protein 90(2011)74 cited
- → Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1(2019)68 cited