Derek C. Cole
Publications by Year
Research Areas
Synthesis and biological activity, Chemical Synthesis and Analysis, Computational Drug Discovery Methods, Alzheimer's disease research and treatments, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → Recent stereoselective synthetic approaches to β-amino acids(1994)456 cited
- → Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin(2009)326 cited
- → Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase(1996)255 cited
- → Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466(2007)217 cited
- → Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease(2008)109 cited
- → Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT6Receptor Agonists and Antagonists(2004)102 cited
- → Acylguanidines as Small-Molecule β-Secretase Inhibitors(2006)100 cited
- → Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets(2007)70 cited
- → Formation of Angularly-Fused Triquinanes by Successive Use of the Pauson-Khand Reaction and Radical Closure(1994)62 cited
- → Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6Receptor Agonist(2007)58 cited