Zachary K. Sweeney
Denali Therapeutics (United States)(US)
Publications by Year
Research Areas
Parkinson's Disease Mechanisms and Treatments, HIV/AIDS drug development and treatment, Biochemical and Molecular Research, Lysosomal Storage Disorders Research, Cellular transport and secretion
Most-Cited Works
- → Ser 1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations(2012)373 cited
- → Effect of selective LRRK2 kinase inhibition on nonhuman primate lung(2015)364 cited
- → Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys(2020)340 cited
- → Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease(2022)237 cited
- → Highly Enantioselective Syntheses of Homopropargylic Alcohols and Dihydrofurans Catalyzed by a Bis(oxazolinyl)pyridine−Scandium Triflate Complex(2001)202 cited
- → Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice(2020)197 cited
- → Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation(2018)177 cited
- → Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors(2012)161 cited
- → Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors(2013)123 cited
- → Dihydrogen Activation by Titanium Sulfide Complexes(1999)122 cited