Ignacio Aliagas
Publications by Year
Research Areas
Computational Drug Discovery Methods, Analytical Chemistry and Chromatography, Melanoma and MAPK Pathways, Scientific Computing and Data Management, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth(2010)1,616 cited
- → Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety(2015)83 cited
- → Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window(2016)76 cited
- → Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors(2011)66 cited
- → Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2(2013)62 cited
- → The evaluation of 25 chiral stationary phases and the utilization of sub-2.0μm coated polysaccharide chiral stationary phases via supercritical fluid chromatography(2013)50 cited
- → Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties(2012)47 cited
- → Predicting Passive Permeability of Drug-like Molecules from Chemical Structure: Where Are We?(2016)47 cited
- → Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life(2018)42 cited
- → Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors(2015)39 cited