Michael A. Brodney
Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Alzheimer's disease research and treatments, Cholinesterase and Neurodegenerative Diseases, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography
Most-Cited Works
- → A Cycloaddition Approach toward the Synthesis of Substituted Indolines and Tetrahydroquinolines(1999)144 cited
- → Utilization of the Intramolecular Cycloaddition−Cationic π-Cyclization of an Isomünchnone Derivative for the Synthesis of (±)-Lycopodine(1997)105 cited
- → Asymmetric Synthesis of the Tricyclic Core of NGF-Inducing Cyathane Diterpenes via a Transition-Metal-Catalyzed [5 + 2] Cycloaddition(2001)93 cited
- → A New Method for the Formation of Octahydroindole Alkaloids via the Intramolecular Diels−Alder Reaction of 2-Amidofurans(1998)84 cited
- → Discovery of the Potent and Selective M1 PAM-AgonistN-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects(2016)83 cited
- → Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation(2018)79 cited
- → Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors(2015)78 cited
- → Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors(2016)76 cited
- → Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase(2017)76 cited
- → Application of Furanyl Carbamate Cycloadditions Toward the Synthesis of Hexahydroindolinone Alkaloids(2001)75 cited