T.C. Appleby
Gilead Sciences (United States)(US)
Publications by Year
Research Areas
Hepatitis C virus research, HIV/AIDS drug development and treatment, Biochemical and Molecular Research, Monoclonal and Polyclonal Antibodies Research, Hepatitis B Virus Studies
Most-Cited Works
- → Clinical targeting of HIV capsid protein with a long-acting small molecule(2020)403 cited
- → Structural basis for RNA replication by the hepatitis C virus polymerase(2015)346 cited
- → RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer(2009)183 cited
- → Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase(2007)170 cited
- → The crystal structure and mechanism of orotidine 5′-monophosphate decarboxylase(2000)161 cited
- → Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9(2017)120 cited
- → Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV(2010)106 cited
- → Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®(2019)84 cited
- → The structure of human 5′-deoxy-5′-methylthioadenosine phosphorylase at 1.7 Å resolution provides insights into substrate binding and catalysis(1999)81 cited
- → Structural basis for substrate selection by the SARS-CoV-2 replicase(2023)79 cited