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William H. Prusoff | doi.page

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William H. Prusoff

Yale University(US)

Publications by Year

Research Areas

Biochemical and Molecular Research, HIV/AIDS drug development and treatment, Synthesis and Characterization of Heterocyclic Compounds, DNA and Nucleic Acid Chemistry, Cancer therapeutics and mechanisms

Most-Cited Works

→ Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction(1973)12,853 cited
→ Synthesis and biological activities of iododeoxyuridine, an analog of thymidine(1959)341 cited
→ Potent and selective in vitro activity of 3' -deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus(1987)261 cited
→ 1-(2,3-Dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent(1989)212 cited
Synthesis and biological activity of several amino analogues of thymidine.(1978)
→ Synthesis and biological activity of several amino analogs of thymidine(1978)172 cited
→

Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-dhoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

(1989)

170 cited

→ Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.(1978)131 cited

→ Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogs of pyrimidine deoxyribonucleosides against retroviruses(1987)122 cited

→ Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol(1989)108 cited