J. Mosley
Molecular Discovery (United Kingdom)(GB)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Drug Transport and Resistance Mechanisms, Neuroscience and Neuropharmacology Research, Alzheimer's disease research and treatments, Enzyme Structure and Function
Most-Cited Works
- → A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response(2012)940 cited
- → RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer(2018)246 cited
- → The crystal structure of phosphorylase b at 6 Å resolution(1974)74 cited
- → Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase(2019)68 cited
- → Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators(2010)66 cited
- → Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability(2008)65 cited
- → Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives(2016)59 cited
- → BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells(2008)57 cited
- → BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character(2008)56 cited
- → Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics(2009)54 cited