Wouter Bruinzeel
Janssen (Belgium)(BE)
Publications by Year
Research Areas
Pain Mechanisms and Treatments, Nerve injury and regeneration, Enzyme Production and Characterization, Neuroscience and Neuropharmacology Research, Alzheimer's disease research and treatments
Most-Cited Works
- → 2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead(2007)145 cited
- → Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein(2009)88 cited
- → Recombinant insect cell expression and purification of human β-secretase (BACE-1) for X-ray crystallography(2002)30 cited
- → Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions(2022)17 cited
- → Recombinant expression, purification and dimerization of the neurotrophic growth factor Artemin for in vitro and in vivo use(2011)6 cited
- → Exceptional Stability of Artemin Neurotrophic Factor Dimers: Effects of Temperature, pH, Buffer and Storage Conditions on Protein Integrity and Activity(2011)4 cited
- → Investigation of signalling cascades induced by neurotrophic synaptolepis factor K7 reveals a critical role for novel PKCε(2013)3 cited
- → IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau(2023)3 cited
- Size based separation of high molecular weight Tau species(2017)