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John I. Manchester | doi.page

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John I. Manchester

Novartis (France)(FR)Novartis (United States)(US)

Publications by Year

Research Areas

Computational Drug Discovery Methods, Cancer therapeutics and mechanisms, Antibiotic Resistance in Bacteria, Protein Structure and Dynamics, Pharmacogenetics and Drug Metabolism

Most-Cited Works

→ ESKAPEing the labyrinth of antibacterial discovery(2015)601 cited
→ A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV(2014)176 cited
→ A New Mechanistic Probe for Cytochrome P450: An Application of Isotope Effect Profiles(1997)131 cited
→ Evaluation of pK_a Estimation Methods on 211 Druglike Compounds(2010)106 cited
→ Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV(2012)88 cited
→ Evolution of Novartis’ Small Molecule Screening Deck Design(2020)80 cited
→

Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents

(2013)

79 cited

→ Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099)(2014)79 cited

→ Evaluating the Efficiency of the Martini Force Field to Study Protein Dimerization in Aqueous and Membrane Environments(2021)63 cited

→ Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa(2015)63 cited