Hiroyuki Sayama
Astellas Pharma (Japan)(JP)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Pharmacogenetics and Drug Metabolism, Monoclonal and Polyclonal Antibodies Research, Cancer Cells and Metastasis, Drug Transport and Resistance Mechanisms
Most-Cited Works
- → Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm(2020)70 cited
- → Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients(2014)54 cited
- → A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins(2019)31 cited
- → Application of Hybrid Approach Based on Empirical and Physiological Concept for Predicting Pharmacokinetics in Humans—Usefulness of Exponent on Prospective Evaluation of Predictability(2012)19 cited
- → Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer(2021)15 cited
- → Development of a Hybrid Physiologically Based Pharmacokinetic Model with Drug‐Specific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics(2013)15 cited
- → Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology(2024)5 cited
- → Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver(2017)5 cited
- → An introduction to QSP modeling for pharmacologists(2019)4 cited
- → 1323 A novel bispecific antibody targeting CD137 and CLDN4 for treating patients with solid tumors(2024)1 cited