Meredith Williams
Cranfield University(GB)Defence Academy of the United Kingdom(GB)
Publications by Year
Research Areas
PI3K/AKT/mTOR signaling in cancer, Hormonal Regulation and Hypertension, Synthetic Organic Chemistry Methods, Chemical Synthesis and Analysis, Chronic Lymphocytic Leukemia Research
Most-Cited Works
- → Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma(2011)195 cited
- → Interaction of tau protein with the dynactin complex(2007)176 cited
- → A generic approach for the catalytic reduction of nitriles(2003)151 cited
- → Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer(2011)99 cited
- → An improved synthesis of bis(1,3-di-N-tert-butylimidazol-2-ylidene)palladium(0) and its use in C–C and C–N coupling reactions(2001)95 cited
- → Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)(2010)80 cited
- → Convenient synthesis of protected primary amines from nitriles(2000)74 cited
- → VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer(2012)71 cited
- → 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice(2008)49 cited
- → The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors(2007)41 cited