Richard Lonsdale
Age UK(GB)GlaxoSmithKline (Poland)(PL)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Metal-Catalyzed Oxygenation Mechanisms, Enzyme Catalysis and Immobilization, Protein Structure and Dynamics, Computational Drug Discovery Methods
Most-Cited Works
- → Structure-based design of targeted covalent inhibitors(2018)331 cited
- → Does Compound I Vary Significantly between Isoforms of Cytochrome P450?(2011)197 cited
- → A practical guide to modelling enzyme-catalysed reactions(2012)179 cited
- → Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity(2017)177 cited
- → P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping(2018)163 cited
- → Inclusion of Dispersion Effects Significantly Improves Accuracy of Calculated Reaction Barriers for Cytochrome P450 Catalyzed Reactions(2010)163 cited
- → Quantum Mechanics/Molecular Mechanics Modeling of Regioselectivity of Drug Metabolism in Cytochrome P450 2C9(2013)150 cited
- → Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase(2016)139 cited
- → Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase(2016)135 cited
- → Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution(2015)120 cited