David Cesarz
Novartis (Switzerland)(CH)
Publications by Year
Research Areas
Enzyme Structure and Function, Protein Kinase Regulation and GTPase Signaling, Peptidase Inhibition and Analysis, Computational Drug Discovery Methods, Synthesis and biological activity
Most-Cited Works
- → N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)(2003)129 cited
- → Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex(1997)121 cited
- → Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships(1999)88 cited
- → Synthesis and Antitumor Activity of Ester-Modified Analogues of Bengamide B(2001)63 cited
- → Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein(1998)48 cited
- → Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry(1997)31 cited
- → The Synthesis of a Novel Inhibitor of B-Raf Kinase(2005)27 cited
- → Synthesis of [3H], [13C215N] and [14C]Sch 66336 (Sarasar™)(2004)6 cited
- Tritium exchange labelling strategies for new drug discovery support(1998)