Gerald Koelsch
Astellas Pharma (United States)(US)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Enzyme Production and Characterization, Computational Drug Discovery Methods, Protein Structure and Dynamics, S100 Proteins and Annexins
Most-Cited Works
- → Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein(2000)772 cited
- → Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor(2000)701 cited
- → Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees(1998)448 cited
- → Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)(2001)224 cited
- → Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)(2000)210 cited
- → Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3(2002)190 cited
- → Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design(2001)183 cited
- → Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates(2000)127 cited
- → BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology(2017)117 cited
- → Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2(2002)112 cited