Yves Ducharme
Merck Canada Inc. (Canada)(CA)
Publications by Year
Research Areas
Phosphodiesterase function and regulation, Inflammatory mediators and NSAID effects, Cholinesterase and Neurodegenerative Diseases, DNA and Nucleic Acid Chemistry, Receptor Mechanisms and Signaling
Most-Cited Works
- → Use of hydrogen bonds to control molecular aggregation. Extensive, self-complementary arrays of donors and acceptors(1988)156 cited
- → MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation(2008)152 cited
- → In VitroCharacterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor(2013)141 cited
- → Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors(2007)128 cited
- → The next generation of PDE4 inhibitors(2001)118 cited
- → Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses(2013)99 cited
- → The C3a receptor antagonist SB 290157 has agonist activity(2005)92 cited
- → The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor(2010)79 cited
- → Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity(2003)66 cited
- → Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability(1996)62 cited