Christopher T. Lemke
Broad Institute(US)
Publications by Year
Research Areas
HIV/AIDS drug development and treatment, Hepatitis C virus research, HIV Research and Treatment, Monoclonal and Polyclonal Antibodies Research, Enzyme Structure and Function
Most-Cited Works
- → Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers(2021)167 cited
- → Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes(2013)124 cited
- → Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein(2012)124 cited
- → Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly(2010)104 cited
- → Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase(2021)86 cited
- → Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex(2022)83 cited
- → Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography(2013)49 cited
- → Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease(2013)49 cited
- → Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335(2011)47 cited
- → Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity(2013)44 cited