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Xiao‐Ping Shi | doi.page

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Xiao‐Ping Shi

Sun Yat-sen University(CN)Fudan University(CN)Zhongshan Hospital(CN)The First Affiliated Hospital, Sun Yat-sen University(CN)First Hospital of Jiaxing(CN)

Publications by Year

Research Areas

Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Drug Transport and Resistance Mechanisms, Cholinesterase and Neurodegenerative Diseases, Antibiotics Pharmacokinetics and Efficacy

Most-Cited Works

→ Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1(2000)864 cited
→ Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state(2000)534 cited
→ Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)(2004)273 cited
→ Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities(2003)168 cited
→ The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain(2001)123 cited
→ Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases(2004)116 cited

→ First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates(2008)

105 cited

→ In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1(2007)100 cited

→ LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease(2006)94 cited

→ Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)(2006)82 cited