R.A. Elling
Novartis (United States)(US)
Publications by Year
Research Areas
Microtubule and mitosis dynamics, Cancer-related Molecular Pathways, Synthesis and biological activity, Cancer therapeutics and mechanisms, DNA Repair Mechanisms
Most-Cited Works
- → Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo(2014)724 cited
- → Discovery of a potent and selective Aurora kinase inhibitor(2008)108 cited
- → Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery(2011)85 cited
- → Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use,(2004)52 cited
- → Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies(2006)46 cited
- → Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism(2016)46 cited
- → Structure-Guided Engineering of Xylitol Dehydrogenase Cosubstrate Specificity(2006)44 cited
- → Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors(2014)41 cited
- → 2-Aminobenzimidazoles as potent Aurora kinase inhibitors(2009)41 cited
- → Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors(2017)40 cited