Nikole Randolph
Array BioPharma (United States)(US)
Publications by Year
Research Areas
Melanoma and MAPK Pathways, Protein Kinase Regulation and GTPase Signaling, Synthesis and biological activity, Pharmacogenetics and Drug Metabolism, DNA Repair Mechanisms
Most-Cited Works
- → Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors(2011)66 cited
- → Potent and selective pyrazole-based inhibitors of B-Raf kinase(2008)65 cited
- → Non-oxime pyrazole based inhibitors of B-Raf kinase(2010)45 cited
- → Non-oxime inhibitors of B-RafV600E kinase(2010)28 cited
- → The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors(2010)26 cited
- → Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells(2002)16 cited
- → Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species(2009)8 cited
- Metabolism of midazolam in various expression systems for human CYP3A4.(1996)
- Kinetics of CYP2D6 and CYP3A4 catalyzed reactions in heterologous expression systems(1996)
- → Abstract B254: Extended target-coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo(2009)