Darren J. Mitchell
Age UK(GB)North Hertfordshire College(GB)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Multiple Myeloma Research and Treatments, Ubiquitin and proteasome pathways, Histone Deacetylase Inhibitors Research, Epigenetics and DNA Methylation
Most-Cited Works
- → 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain(2014)89 cited
- → Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors(2015)83 cited
- → Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors(2015)79 cited
- → A Chemical Probe for the ATAD2 Bromodomain(2016)75 cited
- → Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening(2020)70 cited
- → GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain(2016)65 cited
- → The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor(2020)63 cited
- → Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins(2020)52 cited
- → Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues(2004)51 cited
- → Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists(2005)47 cited