James Osborne
Okinawa Institute of Science and Technology Graduate University(JP)
Publications by Year
Research Areas
Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Asymmetric Hydrogenation and Catalysis, Catalytic C–H Functionalization Methods, Asymmetric Synthesis and Catalysis
Most-Cited Works
- → Catalytic Enantioselective Intermolecular Hydroacylation: Rhodium-Catalyzed Combination of β-S-Aldehydes and 1,3-Disubstituted Allenes(2008)154 cited
- → The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma(2015)68 cited
- → Binder addition methods and binder distribution in high shear and fluidised bed granulation(2010)48 cited
- → Rhodium-catalysed hydroacylation or reductive aldol reactions: a ligand dependent switch of reactivity(2008)45 cited
- → Intermolecular rhodium catalyzed hydroacylation of allenes: the regioselective synthesis of β,γ-unsaturated ketones(2009)38 cited
- → Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)(2016)37 cited
- → Roller compaction: Effect of morphology and amorphous content of lactose powder on product quality(2015)34 cited
- → Investigating the influence of moisture content and pressure on the bonding mechanisms during roller compaction of an amorphous material(2012)31 cited
- → Discovery of a Novel Class of d -Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform(2022)31 cited
- → A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms(2016)28 cited