David A. Quincy

Publications by Year

Research Areas

Synthetic Organic Chemistry Methods, Asymmetric Synthesis and Catalysis, Chemical Synthesis and Analysis, Melanoma and MAPK Pathways, Synthesis and Biological Evaluation

Most-Cited Works

• → Optimizing antibody immobilization strategies for the construction of protein microarrays(2003)515 cited
• In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.(2001)
• → Identification and synthesis of a receptor binding site of human anaphylatoxin C5a(1991)63 cited
• → Enantioselective Diels-Alder reactions: room temperature bis(oxazoline)-zinc, -magnesium, and -copper triflate catalysts(1997)52 cited
• → Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a(1992)49 cited
• → Enantioselective Diels-Alder reactions: novel constrained bis(oxazoline) ligand-metal triflate catalysts(1997)47 cited
• → Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration(2010)44 cited
• → Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures(2013)37 cited
• → Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch(2013)32 cited
• → Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration(2011)32 cited