Lawrence Perez
Publications by Year
Research Areas
Protein Tyrosine Phosphatases, Histone Deacetylase Inhibitors Research, Galectins and Cancer Biology, Bioactive Compounds and Antitumor Agents, Protein Degradation and Inhibitors
Most-Cited Works
- → Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases(2016)909 cited
- → Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor(2016)286 cited
- → Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer(2020)210 cited
- → N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)(2003)129 cited
- → Dual Allosteric Inhibition of SHP2 Phosphatase(2018)127 cited
- → 1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity(2009)106 cited
- → Second-Site NMR Screening with a Spin-Labeled First Ligand(2000)84 cited
- → The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein–Protein Interactions(2013)73 cited
- → Second-Site NMR Screening and Linker Design(2003)66 cited
- → Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors(2011)64 cited