Graeme Hewitt
The Francis Crick Institute(GB)London Cancer(GB)
Publications by Year
Research Areas
DNA Repair Mechanisms, PARP inhibition in cancer therapy, Telomeres, Telomerase, and Senescence, CRISPR and Genetic Engineering, Autophagy in Disease and Therapy
Most-Cited Works
- → Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence(2012)890 cited
- → Chronic inflammation induces telomere dysfunction and accelerates ageing in mice(2014)775 cited
- → Mitochondria are required for pro‐ageing features of the senescent phenotype(2016)753 cited
- → Lysosome-mediated processing of chromatin in senescence(2013)526 cited
- → Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance(2021)340 cited
- → Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN(2016)244 cited
- → Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?(2014)188 cited
- → DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease(2015)169 cited
- → Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance(2016)160 cited
- → Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD(2020)160 cited