Dennis S. Yamashita
Publications by Year
Research Areas
Bone Metabolism and Diseases, Protease and Inhibitor Mechanisms, Natural product bioactivities and synthesis, Receptor Mechanisms and Signaling, X-ray Diffraction in Crystallography
Most-Cited Works
- → A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine(2013)639 cited
- → Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance(2010)364 cited
- → Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12(1993)203 cited
- → Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain(2013)196 cited
- → Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase(2008)155 cited
- → DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12(1993)148 cited
- → Cathepsin K and the Design of Inhibitors of Cathepsin K(2000)136 cited
- → A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys(2006)136 cited
- → A new synthesis of substituted furans(1989)130 cited
- → Total synthesis of calicheamicinone: new arrangements for actuation of the reductive cycloaromatization of aglycon congeners(1991)107 cited