Romain Gosmini
Galapagos (France)(FR)
Publications by Year
Research Areas
Asymmetric Synthesis and Catalysis, Protein Degradation and Inhibitors, Osteoarthritis Treatment and Mechanisms, Chemical Synthesis and Analysis, Multiple Myeloma Research and Treatments
Most-Cited Works
- → Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains(2011)334 cited
- → Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains(2013)302 cited
- → BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models(2013)203 cited
- → The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor(2014)187 cited
- → From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151(2012)118 cited
- → Preparation and Utilization of Chiral Dihydropyridines. Synthesis of Chiral Indoloquinolizines and Benzoquinolizines(1994)73 cited
- → Chiral animals: Powerful auxiliaries in asymmetric synthesis(1996)55 cited
- → Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis(2021)54 cited
- → Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84(2017)48 cited
- → Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial(2020)43 cited