Joseph R. Stock
Novo Nordisk (United States)(US)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Chemical Synthesis and Analysis, Cholinesterase and Neurodegenerative Diseases, Pediatric Urology and Nephrology Studies
Most-Cited Works
- → Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease(2008)109 cited
- → Acylguanidines as Small-Molecule β-Secretase Inhibitors(2006)100 cited
- → Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism(2016)70 cited
- → Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets(2007)70 cited
- → Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6Receptor Agonist(2007)58 cited
- → A fluorescent assay suitable for inhibitor screening and vanin tissue quantification(2009)47 cited
- → Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors(2008)45 cited
- → N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists(2004)43 cited
- → Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads(2016)37 cited
- → Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1′ substrate binding pocket(2007)36 cited