Morgan S. Gadd

Publications by Year

Research Areas

Ubiquitin and proteasome pathways, Cancer, Hypoxia, and Metabolism, Protein Degradation and Inhibitors, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography

Most-Cited Works

• → Structural basis of PROTAC cooperative recognition for selective protein degradation(2017)1,136 cited
• → Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities(2014)396 cited
• → Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition(2016)234 cited
• → Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)(2017)158 cited
• → Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex(2017)150 cited
• → 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation(2018)145 cited
• → Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification(2011)39 cited
• → Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases(2022)27 cited
• → A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions(2013)26 cited
• → Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases(2015)21 cited