Justin T. Hole
Eli Lilly (United States)(US)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Neuroinflammation and Neurodegeneration Mechanisms, Computational Drug Discovery Methods, Intracerebral and Subarachnoid Hemorrhage Research, Monoclonal and Polyclonal Antibodies Research
Most-Cited Works
- → TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques(2016)865 cited
- → A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice(2012)443 cited
- → Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model(2018)89 cited
- → Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice(2023)80 cited
- → [O2–14–05]: PRECLINICAL CHARACTERIZATION OF AN ANTIBODY [LY3303560] TARGETING AGGREGATED TAU(2017)42 cited
- → Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease(2024)21 cited
- → O1‐10‐03: COMBINATION THERAPY WITH A PLAQUE‐SPECIFIC ABETA ANTIBODY AND BACE INHIBITOR RESULTS IN DRAMATIC PLAQUE LOWERING IN AGED PDAPP TRANSGENIC MICE(2014)7 cited
- → P4‐401: Combination Therapy with a Plaque‐Specific Abeta Antibody And A Bace Inhibitor Results in Dramatic Plaque Reduction in a Dose‐Dependent Manner in Aged Pdapp Transgenic Mice(2016)2 cited
- → P1‐114: MEASUREMENT OF ENDOGENOUS MOUSE TAU IN CEREBROSPINAL FLUID FROM AGED PDAPP MICE FOLLOWING TREATMENT WITH AB‐LOWERING COMPOUNDS(2018)2 cited
- → P3‐067: Development of a Highly Sensitive TAU Immunoassay to Measure Endogenous Murine TAU in Mouse Cerebrospinal Fluid(2016)