Tomoya Sameshima
Takeda (Japan)(JP)
Publications by Year
Research Areas
Crystallization and Solubility Studies, Protein Degradation and Inhibitors, X-ray Diffraction in Crystallography, Enzyme Structure and Function, Protein Structure and Dynamics
Most-Cited Works
- → K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology(2017)111 cited
- → Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins(2013)108 cited
- → Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation(2018)103 cited
- → Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation(2017)101 cited
- → Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands(2017)98 cited
- → Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d(2017)80 cited
- → Discovery of 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors(2018)61 cited
- → Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)(2018)53 cited
- → Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase(2018)51 cited
- → Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay(2015)49 cited