Kimberly F. Fennell
Pfizer (United States)(US)
Publications by Year
Research Areas
SARS-CoV-2 and COVID-19 Research, Receptor Mechanisms and Signaling, Phosphodiesterase function and regulation, Chemical synthesis and alkaloids, Protein Structure and Dynamics
Most-Cited Works
- → Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants(2022)171 cited
- → Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct(2009)161 cited
- → Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins(2020)120 cited
- → Activation of Human Liver Glycogen Phosphorylase by Alteration of the Secondary Structure and Packing of the Catalytic Core(2000)96 cited
- → Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase(2017)76 cited
- → Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia(2011)52 cited
- → An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism(2023)32 cited
- → Discovery of 3-Cyano- N -(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H -pyrrolo[2,3- b ]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist(2018)32 cited
- → Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor(2017)32 cited
- → New kinase regulation mechanism found in HipBA: a bacterial persistence switch(2009)27 cited