Robert Downham
Domainex (United Kingdom)(GB)
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Carbohydrate Chemistry and Synthesis, Chemical Synthesis and Reactions, Marine Sponges and Natural Products, Marine Toxins and Detection Methods
Most-Cited Works
- → Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design(2010)261 cited
- → Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency(2010)185 cited
- → Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery(2007)138 cited
- → Total Synthesis of (−)-Sarain A(2007)110 cited
- → Total synthesis of the protein phosphatase inhibitor okadaic acid(1998)65 cited
- → Asymmetric Construction of the Diazatricyclic Core of the Marine Alkaloids Sarains A−C(1998)43 cited
- → Dispiroketals: a new functional group for organic synthesis(1995)40 cited
- → Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates(1994)39 cited
- → Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates(1994)36 cited
- → 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction(2017)33 cited