Stefan Pype
Janssen (Belgium)(BE)
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Neuroscience and Neuropharmacology Research, Alzheimer's disease research and treatments, RNA Research and Splicing, NF-κB Signaling Pathways
Most-Cited Works
- → Identification of a new caspase homologue: caspase-14(1998)141 cited
- → TTRAP, a Novel Protein That Associates with CD40, Tumor Necrosis Factor (TNF) Receptor-75 and TNF Receptor-associated Factors (TRAFs), and That Inhibits Nuclear Factor-κB Activation(2000)129 cited
- → Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor(2012)85 cited
- → Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 H )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor(2014)56 cited
- → Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor(2014)47 cited
- → Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813(2015)46 cited
- → Characterization of amyloid β peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein(2003)46 cited
- → NF-κB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells(2001)44 cited
- → The functional γ-secretase inhibitor prevents production of amyloid β 1–34 in human and murine cell lines(2001)38 cited
- → Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures(2017)25 cited