James P. Driscoll
Bristol-Myers Squibb (Germany)(DE)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Biochemical and Molecular Research, Synthesis and Biological Evaluation, Platelet Disorders and Treatments, Glycosylation and Glycoproteins Research
Most-Cited Works
- → Lead identification of novel and selective TYK2 inhibitors(2013)122 cited
- → In vitroandin vivopharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin(2018)100 cited
- → Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors(2013)97 cited
- → Biotransformation and bioactivation reactions of alicyclic amines in drug molecules(2014)79 cited
- → Treatment of Parainfluenza 3 Infection With DAS181 in a Patient After Allogeneic Stem Cell Transplantation(2011)61 cited
- → Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV(2013)56 cited
- → A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif(2007)51 cited
- → Metabolism and Bioactivation: It’s Time to Expect the Unexpected(2020)31 cited
- → Bioactivation of Phencyclidine in Rat and Human Liver Microsomes and Recombinant P450 2B Enzymes: Evidence for the Formation of a Novel Quinone Methide Intermediate(2007)28 cited
- → Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase(2016)24 cited