Claude G. Lerner

Publications by Year

Research Areas

RNA and protein synthesis mechanisms, Bacterial Genetics and Biotechnology, Bacteriophages and microbial interactions, Protein Structure and Dynamics, Pneumonia and Respiratory Infections

Most-Cited Works

• → Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability(1990)278 cited
• → ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens(2004)230 cited
• → Pleiotropic changes resulting from depletion of Era, an essential GTP‐binding protein in Escherichia coli(1991)123 cited
• The Escherichia coli Ras-like protein (Era) has GTPase activity and is essential for cell growth.(1988)
• → Nucleoside diphosphate kinase from Escherichia coli; its overproduction and sequence comparison with eukaryotic enzymes(1991)84 cited
• → An Ultraefficient Affinity-Based High-Throughout Screening Process: Application to Bacterial Cell Wall Biosynthesis Enzyme MurF(2006)73 cited
• → Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization(2004)70 cited
• → Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure(2005)62 cited
• → Cloning and structure of the Bacillus subtilis aspartate transcarbamylase gene (pyrB).(1986)55 cited
• → Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase(1992)48 cited