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Jay Wrobel | doi.page

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Jay Wrobel

Fox Chase Chemical Diversity Center(US)

Publications by Year

Research Areas

Estrogen and related hormone effects, Cholesterol and Lipid Metabolism, Drug Transport and Resistance Mechanisms, Bioactive Compounds and Antitumor Agents, Chemical Synthesis and Analysis

Most-Cited Works

→ Mechanism and synthetic utility of boron trifluoride etherate-promoted organolithium additions(1984)230 cited
→ Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)(2008)196 cited
→ Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents(1992)187 cited
→ Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)(2009)161 cited
→ PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes(1999)126 cited
→ Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines(2002)116 cited

→ LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse(2009)106 cited

→ 6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists(2002)106 cited

→ Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses(2014)99 cited

→ Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget(2005)91 cited