Chris De Savi
Woomera Therapeutics(US)C4 Therapeutics (United States)(US)
Publications by Year
Research Areas
Estrogen and related hormone effects, Cancer-related Molecular Pathways, Carbohydrate Chemistry and Synthesis, Cancer therapeutics and mechanisms, Synthetic Organic Chemistry Methods
Most-Cited Works
- → Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase(2007)273 cited
- → AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1 -Mutant Breast Tumors in Preclinical Models(2016)174 cited
- → Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist(2015)159 cited
- → Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer(2022)154 cited
- → Total Synthesis of the Microtubule-Stabilizing Agent (−)-Laulimalide(2001)114 cited
- → Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply