Natacha Bienvenu
Galapagos (France)(FR)
Publications by Year
Research Areas
Sphingolipid Metabolism and Signaling, Research on Leishmaniasis Studies, Carbohydrate Chemistry and Synthesis, Osteoarthritis Treatment and Mechanisms, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- a ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis(2017)137 cited
- → Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic(2014)109 cited
- → Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors(2017)60 cited
- → Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis(2021)54 cited
- → Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312(2023)20 cited
- → Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector(2024)8 cited
- → Design, Synthesis, and Biological Implications of Autotaxin inhibitors with a Three-Point lock binding mode(2025)2 cited
- → Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors(2018)