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George D. Hartman | doi.page

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George D. Hartman

Joint BioEnergy Institute(US)

Publications by Year

Research Areas

Synthesis and Biological Evaluation, Platelet Disorders and Treatments, Cell Adhesion Molecules Research, Neuroscience and Neuropharmacology Research, Protein Kinase Regulation and GTPase Signaling

Most-Cited Works

→ Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice(1995)538 cited
→ Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors(2004)499 cited
→ Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia(2010)370 cited
→ Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors(1992)295 cited
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.(2001)
→ Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences(2003)203 cited

→ Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp(1994)

178 cited

→ Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo(2004)170 cited

→ Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer(2008)156 cited

→ High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein(2015)151 cited