Michael J. Krambis
Eli Lilly (United States)(US)
Publications by Year
Research Areas
Ion channel regulation and function, Neuroscience and Neuropharmacology Research, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Pain Mechanisms and Treatments
Most-Cited Works
- → A-803467, a potent and selective Na v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat(2007)520 cited
- → Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels(2013)241 cited
- → Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain(2008)84 cited
- → Synthesis of (−)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation(2017)64 cited
- → Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy(2016)47 cited
- → Structural Locus of the pH Gate in the Kir1.1 Inward Rectifier Channel(2005)37 cited
- → Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy(2018)35 cited
- → Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain(2010)34 cited
- → The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats(2019)33 cited
- → Permeant Cations and Blockers Modulate pH Gating of ROMK Channels(2003)31 cited