Jessica J. Huck
Innovation Research Center(US)
Publications by Year
Research Areas
Microtubule and mitosis dynamics, Cancer-related Molecular Pathways, Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Cancer Treatment and Pharmacology
Most-Cited Works
- → A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment(2018)441 cited
- → Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase(2007)413 cited
- → Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays(2011)300 cited
- → MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo(2010)117 cited
- → MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors(2015)108 cited
- → Translational Exposure–Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib)(2014)34 cited
- → Preclinical pharmacokinetic/pharmacodynamic/efficacy relationships for alisertib, an investigational small-molecule inhibitor of Aurora A kinase(2013)24 cited
- MLN8237: an orally active small molecule inhibitor of Aurora A kinase in phase I clinical trials(2008)
- → Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models(2009)11 cited
- Preclinical antitumor activity with MLN8054, a small molecule Aurora A kinase inhibitor(2006)