Suzanne Kyle
Newcastle University(GB)
Publications by Year
Research Areas
PARP inhibition in cancer therapy, DNA Repair Mechanisms, Cancer therapeutics and mechanisms, Chemotherapy-induced cardiotoxicity and mitigation, Electron Spin Resonance Studies
Most-Cited Works
- → Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase(2005)5,108 cited
- → Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361(2004)483 cited
- → Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial(2007)298 cited
- → Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors(2010)267 cited
- → Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2(2010)258 cited
- Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.(2000)
- → Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines(2011)192 cited
- → Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells(2004)165 cited
- → Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer(2013)157 cited
- → Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure(2002)135 cited