Siew Kuen Yeap
Publications by Year
Research Areas
HER2/EGFR in Cancer Research, Computational Drug Discovery Methods, Lung Cancer Treatments and Mutations, Estrogen and related hormone effects, Cancer therapeutics and mechanisms
Most-Cited Works
- → GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer(2021)132 cited
- → Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation(2014)61 cited
- → Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor(2016)33 cited
- → Designing Compound Subsets: Comparison of Random and Rational Approaches Using Statistical Simulation(2007)19 cited
- → Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets(2012)16 cited
- → Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927(2019)14 cited
- → CCDC 2167969: Experimental Crystal Structure Determination(2022)