John D. Trzupek
Pfizer (United States)(US)
Publications by Year
Research Areas
Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Cancer therapeutics and mechanisms, Crystallography and molecular interactions, DNA and Nucleic Acid Chemistry
Most-Cited Works
- → Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit(2012)195 cited
- → Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases(2018)163 cited
- → Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance(2015)143 cited
- → Discovery of Clinical Candidate 1-{[(2 S ,3 S ,4 S )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design(2017)139 cited
- → Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I(2009)119 cited
- → Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit(2016)108 cited
- → Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization(2010)78 cited
- → Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan(2010)76 cited
- → Asymmetric Total Synthesis of (+)- and ent-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer(2006)75 cited
- → Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin(2006)61 cited