Graham A. Showell
Publications by Year
Research Areas
Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Receptor Mechanisms and Signaling, Synthesis and biological activity, Computational Drug Discovery Methods
Most-Cited Works
- → Chemistry challenges in lead optimization: silicon isosteres in drug discovery(2003)420 cited
- → Exploitation of silicon medicinal chemistry in drug discovery(2004)154 cited
- → Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors(1990)132 cited
- → Silicon Switches of Marketed Drugs(2006)123 cited
- → Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization(2006)91 cited
- → Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry(2006)66 cited
- → Tetrahydropyridyloxadiazoles: semi-rigid muscarinic ligands(1991)64 cited
- → Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene(2005)61 cited
- → High-Affinity and Potent, Water-Soluble 5-Amino-1,4-benzodiazepine CCKB/Gastrin Receptor Antagonists Containing a Cationic Solubilizing Group(1994)61 cited
- → (R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis(2006)57 cited