Jason Halladay
San Francisco Public Library(US)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Colorectal Cancer Treatments and Studies, Drug Transport and Resistance Mechanisms, Cancer therapeutics and mechanisms, Computational Drug Discovery Methods
Most-Cited Works
- → GDC-0449—A potent inhibitor of the hedgehog pathway(2009)385 cited
- → Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)(2012)247 cited
- → Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity(2011)136 cited
- → Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors(2013)123 cited
- → Lead identification of novel and selective TYK2 inhibitors(2013)122 cited
- → Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors(2013)97 cited
- → Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton’s Tyrosine Kinase Inhibitor(2011)74 cited
- → Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates(2022)66 cited
- → Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs(2012)63 cited
- → A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834(2015)61 cited